Re: [PyrNet-L] Degenerative Myelopathy

[MGApeach@aol.com]

Well, we went over this disease some last quarter in Pathology and diseases, 
and we are going to go into it in some more depth in anatomy and physiology. 
There is a similar disease in horses called degenerative encephalomylopathy 
that degenerates around the brain stem. I pulled out my disease bible, the 
Merk Veterinary Manual to read more about this condition. (I think everyone 
needs a Merk, I had to have it for my class, I think it is a great reference, 
even for pet owners) Here is what I found out.....

It is a non-inflamitory, slow progressing degeneration of the myelin and 
axons in the white matter of the spinal cord.  Apparently it progresses in 
6-12 months. It says the cause is unknown, but "genetic factors are assumed." 
The animals are usually over five years in age. They are usually presented 
with an "insidious onset of nonpainful, pelvic ataxia and paraperisis. Pelvic 
reflexes are usually normal, or exaggerated, but in -10% of cases, patellar 
reflexes are depressed, reflecting involvement of the lumbar dorsal nerve 
roots. (lower back, top side)"

It also says that early cases can be confused with other orthopedic 
disorders, and that Myelography and CSF are essential to rule out compressive 
and inflammatory disorders. The recommended treatment by the Merk Manual is 
aminocaproic acid (500 mg PO three times daily), along with Vitamin therapy 
with B and E vitamins, and exercise. 

Is there a veterinary university in your area? They are always up on new 
protocols in treatment for different diseases. Ask your veterinarian if he 
could give you a referral. With a disease such as this, I would also get a 
second opinion, just to be sure. Good Luck, I know that you will be in all of 
our prayers.

Melissa