Re: [pyrnet] Pyrs without Dwarf producing ancestors

["Janice Swenson" <janices@austin.rr.com>]

On 27 Dec 2000, at 14:44, Smith, Deborah wrote:
>     That's true.  Could you list a few diseases/problems that are
>     dominate?

The list has been talking about one that is probably dominant, sub-
aortic stenosis, and possibly it's dominant w/modifiers or limited 
penetrance.  The research results haven't been announced yet in 
the research that newfs are involved in on mode of inheritance so 
until then have to go on dominant.  In Bouviers, another research 
project, it's thought to be recessive but are making allowances in 
case it's dominant with limited penetrance.  

Which should make it easy to get it out except for one thing we 
come across dogs that clear heart checks, dopplers, and upon 
post mortem found to have SAS in newfs.  It's the subclinical ones 
that get through, so who do you pull from a breeding program.  In 
newfs it's thought there's not an unaffected line.  And a dog with 
mild disease does not necessarily throw the same, mild can throw 
severes, the drop down dead cases.  

I've got a newf here who both parents cleared heart checks, she 
cleared her 10 week heart check for SAS, dopplered.  She was 
pulled from a breeding program because of another heart problem 
but has a good long term prognosis and I have her to show her.  
She didn't clear her 1 yr old heart check from SAS, but still has a 
good long term prognosis.  

The affected dogs and questionable ones you do have to pull out of 
any breeding program.  The others you do the best you can until a 
marker is found.  

And some of the other heart valve problems are not dominant, but 
probably polygenic.  These usually hit a dog when older but in 
some breeds have turned out to be problems and are still genetic 
based, mitral valve regurgitation, tricuspid valve regurgitation, etc.  

Website on genetics that might be of use:   
http://bowlingsite.mcf.com/Genetics/Genetics.html 


Janice, janices@austin.rr.com
Lana & Linsey (newfs), Sonny (pyr)  
http://home.austin.rr.com/janices
Hutto, TX